Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries
نویسندگان
چکیده
منابع مشابه
Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.
CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established TgNotch3R169C mouse model develops characteristic features of the human disease, wi...
متن کاملNotch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.
OBJECTIVE Notch3, a member of the evolutionary conserved Notch receptor family, is primarily expressed in vascular smooth muscle cells. Genetic studies in human and mice revealed a critical role for Notch3 in the structural integrity of distal resistance arteries by regulating arterial differentiation and postnatal maturation. METHODS AND RESULTS We investigated the role of Notch3 in vascular...
متن کاملTRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries.
We tested the hypothesis that TRPC3, a member of the canonical transient receptor potential (TRP) family of channels, mediates agonist-induced depolarization of arterial smooth muscle cells (SMCs). In support of this hypothesis, we observed that suppression of arterial SMC TRPC3 expression with antisense oligodeoxynucleotides significantly decreased the depolarization and constriction of intact...
متن کاملPathological changes in temporal arteries removed from unselected cadavers.
Progressive degenerative changes in ageing temporal arteries are described. These changes are usually severe in elderly patients, hence their presence in diagnostic biopsies provides no evidence of temporal arteritis past or present. In two patients in the series of random necropsies examined there were changes in the temporal arteries identical with those seen in patients known to have suffere...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension
سال: 2017
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.116.08015